1 Title : The Determinants of Activity and Specificity in Actinorhodin Type II
نویسندگان
چکیده
منابع مشابه
The determinants of activity and specificity in actinorhodin type II polyketide ketoreductase.
In the actinorhodin type II polyketide synthase, the first polyketide modification is a regiospecific C9-carbonyl reduction, catalyzed by the ketoreductase (actKR). Our previous studies identified the actKR 94-PGG-96 motif as a determinant of stereospecificity. The molecular basis for reduction regiospecificity is, however, not well understood. In this study, we examined the activities of 20 ac...
متن کاملSelf-Care Behaviors’ Glycemic Control and its Related Factors in Type II Diabetes Women Patients
Introduction: Diabetes is the most common metabolic disorder and can have devastating complications. The objective of this study was to determine self-care behaviors for glycemic control and its related factors in type II diabetes women patients. Materials and Methods: This cross-sectional study, conducted in 2016 on a randomly selected sample of 120 women volunteers, aged over 30 years, referr...
متن کاملRelationship between sleep quality and self-management in type II diabetes patients
Background & Aim: Sleep disturbances in type II diabetes patients due to insulin resistance is a risk factor for the exacerbation of the disease. Therefore, assessment of the factors affecting the improvement of sleep in diabetic patients is a necessity for health care providers. The aim of this study was to investigate the relationship between sleep quality and self-management in type 2 diabet...
متن کاملLocalization of the ActIII actinorhodin polyketide ketoreductase to the cell wall.
Structurally diverse polyketides provide a rich reservoir of bioactive molecules. Actinorhodin, a model aromatic polyketide, is synthesized by minimal type II polyketide synthase and tailoring enzymes. The ActIII actinorhodin ketoreductase is a key tailoring enzyme in actinorhodin biosynthesis. With purified antibodies against actinorhodin polyketide synthase alpha subunit (KSalpha) and ketored...
متن کاملAngiotensin II type 1 receptor blocker losartan attenuates locomotor, anxiety-like behavior and passive avoidance learning deficits in a sub-chronic stress model
Objective(s): Stress alters sensory and cognitive function in humans and animals. Angiotensin (AT) receptors have demonstrated well-established interactions in sets of physiological phenomena. AT1 receptors can play a part in stress-induced activation of hypothalamic-pituitary-adrenal (HPA) axis; besides angiotensinergic neurotransmission plays a pivotal role in stress-evoked physiological resp...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2017